Effects of mutations to spike of SARS-CoV-2 XBB.1.5 on escape from antibodies

This is is an interactive chart. Mouseover points for details and measurements, and use the top zoom bar to zoom in on specific sites. The options at the bottom let you only show escape for sites with some minimal functional effect, choose the site summary metric, or floor the escape at zero.

The line plots at top show the escape at each site across all antibodies and for individual antibodies, and the heatmaps show the effects of individual mutations on antibody escape or functions of the protein.

Analysis by Bernadeta Dadonaite and Jesse Bloom (2024).

See https://github.com/dms-vep/SARS-CoV-2_XBB.1.5_spike_DMS_VRC_mAbs for code/data.